Avantor, Inc. (NYSE: AVTR), a leading global provider of critical products and services to the life sciences and advanced technologies industries, has unveiled two groundbreaking products designed to optimize the gene therapy harvest process sustainably: J.T.Baker® Cell Lysis Solution and J.T.Baker® Endonuclease.
“These products are pivotal for gene therapy manufacturers seeking enhanced harvest efficiency while preserving the integrity of valuable viral particles,” said Benoit Gourdier, Executive Vice President of Bioscience Production at Avantor. “They also meet the rising demand from biopharmaceutical customers for environmentally responsible solutions.”
Avantor’s scientists developed J.T.Baker® Cell Lysis Solution as a safe and efficient alternative to Octoxynol-9, listed as a substance of very high concern by the European Chemicals Agency under REACH regulations due to environmental toxicity concerns. This biodegradable solution demonstrates low ecotoxicity and is used in the upstream harvesting process to release adeno-associated virus (AAV) from host cells, a critical step in gene therapy workflows. Avantor’s studies indicate that the solution enhances viral vector release efficiency across various cell densities and temperatures while safeguarding viral particle integrity during processing.
Offered as a ready-to-use reagent without requiring refrigeration or complex preparation, J.T.Baker® Cell Lysis Solution simplifies the harvest process and minimizes contamination risks by eliminating pre-dilution and filtration needs, thereby reducing bioburden risks. Its high-concentration formulation also reduces viscosity and foam generation, optimizing bioreactor utilization.
When combined with J.T.Baker® Endonuclease, which effectively removes residual impurities, these solutions further streamline the harvest process by reducing steps and enhancing efficiency. Together, they ensure robust DNA clearance and mitigate aggregation, tailored to various scales with a range of cGMP grade size options.
Avantor’s J.T.Baker® Cell Lysis Solution and J.T.Baker® Endonuclease complement a comprehensive lineup of modular and scalable chemical and fluid handling solutions. For more details, please visit our website for additional product information.
