Global Oligonucleotide Market Forecast 2025–2030: Therapeutic Demand Drives Growth

Market Outlook: Explosive Growth to 2030

The global oligonucleotide synthesis market is forecast to grow at a compound annual growth rate (CAGR) of 18.6%, reaching an estimated USD 24.7 billion by 2030, up from USD 10.5 billion in 2025. This dramatic increase reflects surging demand across therapeutic, diagnostic, and research applications, driven by scientific breakthroughs, rising investments, and the increasing adoption of precision medicine.

Strategic Value of the Report

This report is an essential tool for both established players and new market entrants. It delivers:

• Revenue projections across the global market and its key subsegments.
• Insights into the competitive landscape, revealing strategic positioning opportunities.
• Analysis of critical market forces—drivers, restraints, challenges, trends, and emerging opportunities.
• Support for crafting tailored go-to-market strategies and positioning decisions.

In short, it delivers a pulse on industry dynamics, equipping stakeholders to align with evolving market needs.

Core Growth Drivers

1. Rising Demand for Synthetic Oligonucleotides

• Primers and probes for PCR, qPCR, and next-gen sequencing are seeing rapid growth in research and diagnostics.
• RNA technologies—antisense oligos (ASOs) and small interfering RNAs (siRNAs)—are fueling therapeutic demand due to their precision and ability to target genetic disorders.

2. Technological Advancements

• Innovation in solid-phase synthesis, high-throughput platforms, error correction, and automation has dramatically increased yield and decreased costs.
• Advances in scalable manufacturing and high purity reagents are making large-scale production economically viable.

3. Health Research & Synthetic Biology Funding

• Support from governments and private investors is accelerating research in oligo-based therapies.
• Synthetic biology initiatives are expanding applications beyond healthcare, boosting foundational demand.

4. Shift Toward Precision & Personalized Medicine

• ASOs and siRNAs offer targeted treatment options, especially for inherited and rare conditions.
• Custom oligos are critical in personalized pharmacogenomics and companion diagnostics.

Headwinds to Consider

1. Complexity of Therapeutics

• Large, chemically modified oligonucleotides are challenging to synthesize and purify.
• Efficient delivery to target tissues remains a bottleneck.

2. Regulatory Gaps

• Guidelines for classification, testing, and quality control are not yet standardized globally.
• Manufacturers must navigate fragmented and evolving regulatory frameworks.

Market Opportunities

• Emerging economies: Growing biotech infrastructure across Asia, Latin America, and Africa opens new markets.
• Research investments: Increased R&D activity in universities, CROs, and biotechs will drive demand for novel oligos.

Key Challenges

• Standardization: Limited harmonization in quality metrics and production processes complicates market entry.
• Drug delivery: Enhancing tissue-specific delivery systems is critical for therapeutic success.

Emerging Market Trends

• Development of sustainable, large-scale synthesis methods to meet global demand.
• Ongoing M&A and partnerships among oligo manufacturers and therapeutic developers for market consolidation.
• Expansion of ASO-based treatments for neurological and rare diseases.
• Acquisitions and collaborations to advance drug delivery vehicles like lipid nanoparticles and conjugates.

Market Segmentation

By Product Category

1. Oligonucleotide-Based Drugs
   • Dominated the market in 2024 due to clinical and commercial success.
   • ASOs and siRNAs are effectively addressing genetic and rare diseases.
   • Growing pipeline of RNA therapeutics targeting disorders like Duchenne muscular dystrophy, hypercholesterolemia, and more.
2. Synthesized Oligonucleotides
   • Includes primers, probes, aptamers, and guide RNAs.
   • Widely adopted in PCR tests, molecular diagnostics, and CRISPR workflows.
3. Reagents & Consumables
   • Supports synthesis platforms —++ phosphoramidites, solid supports, coupling reagents, solvents, and deprotection kits.
4. Equipment
   • Automated synthesizers, purification systems, and analytical instruments.

By Application

• Therapeutics: Held the largest market share in 2024
  • ASOs and siRNAs are increasingly used for neurological, rare, cardiovascular, and oncology indications.
  • Advancements in synthesis and delivery technologies are unlocking new therapeutic targets based on precise understanding of disease biology.
• Research Applications: Include gene expression studies, CRISPR R&D, synthetic biology, and functional genomics.
• Diagnostics: Used in test kits, companion diagnostics, and probe‐based assays for infectious and hereditary diseases.

Geographic Breakdown

• North America dominated in 2024.
  • Fueled by concentrated R&D spending, advanced healthcare infrastructure, and supportive reimbursement environments.
  • Presence of global leaders such as Danaher, Thermo Fisher, and Biogen aids market depth.
• Europe and Asia-Pacific show fast-growing opportunities, propelled by increased biotech investments, improved regulatory ecosystems, and rising disease burden.
• Rest of World: Latin America, Middle East, and Africa poised for expansion via improved healthcare access and research capabilities.

Competitive Landscape: Leading Players

Providers of Research & Diagnostic Oligos

• Danaher Corporation (US)
• Thermo Fisher Scientific (US)
• Merck KGaA (Germany)
• Eurofins Scientific (Luxembourg)
• LGC Limited (UK)
• Agilent Technologies (US)
• Kaneka Corporation (Japan)
• Maravai LifeSciences (US)
• Azenta US Inc. (US)
• Twist Bioscience (US)
• GenScript (US)

Therapeutic Developers

• Biogen (US)
• Alnylam Pharmaceuticals (US)
• Sarepta Therapeutics (US)
• AstraZeneca (UK)
• Astellas Pharma (Japan)
• Jazz Pharmaceuticals (Ireland)
• Nippon Shinyaku (Japan)
• Ionis Pharmaceuticals (US)
• Novartis (Switzerland)

Additional notable companies: Oligomaker, Biolegio, Biolytic, Biocomma, Revvity, Bio‑Synthesis, Creative Biogene, Reprocell.

In‑Depth Case Studies

1. Thermo Fisher: Scaled up the production of large-volume dye-labeled oligos, optimizing delivery timelines for genomic service clients.
2. Baker Lab: Implemented Twist Bioscience’s oligo pools for high-throughput analysis of protein folding dynamics.
3. Spinraza® (nusinersen): Treatment for spinal muscular atrophy demonstrated significant motor function gains in adolescents with late-onset SMA, highlighting ASO therapeutic potential.

Why This Matters to Your Business

1. High Growth Potential
   • With a projected asset base of USD 24.7 billion by 2030, rapid expansion provides fertile ground for investment.
2. Multiple Market Entry Points
   • Opportunities abound across product categories, applications, and geographic regions.
3. Differentiation Through Innovation
   • Rapid advancements and unmet delivery challenges create space for innovators and strategic partnerships.
4. Regulatory Positioning
   • Standardization efforts and global policy alignment create strategic windows for early adopters.

Report Snapshot

For more information about this report visit https://www.researchandmarkets.com/r/h90tux

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